PFKFB1 Rabbit Polyclonal Antibody

CAT#: TA350927

Rabbit Polyclonal Anti-PFKFB1 Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human PFKFB1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
• Database Link:
  NP_002616
  Entrez Gene 18639 MouseEntrez Gene 24638 RatEntrez Gene 5207 Human
  UniProt ID P16118
• Background: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.
• Synonyms: F6PK; HL2K; PFRX

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Fructose and mannose metabolism