CYP46 (CYP46A1) Rabbit Polyclonal Antibody

CAT#: TA351117

Rabbit Polyclonal Anti-CYP46A1 Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Human lymphoma tissue Primary antibody: TA351117 (CYP46A1 Antibody) at dilution 1/200 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 1 minute

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA351117 (CYP46A1 Antibody) at dilution 1/15 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA351117 (CYP46A1 Antibody) at dilution 1/15, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA351117 (CYP46A1 Antibody) at dilution 1/15 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA351117 (CYP46A1 Antibody) at dilution 1/15, treated with synthetic peptide. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Human lymphoma tissue
  IHC: 25-100
  Positive control: Human brain
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human CYP46A1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 57 kDa
• Gene Name: cytochrome P450 family 46 subfamily A member 1
• Database Link:
  NP_006659
  Entrez Gene 13116 MouseEntrez Gene 362782 RatEntrez Gene 10858 Human
  UniProt ID Q9Y6A2
• Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
• Synonyms: CP46; CYP46

Reference Data

• Protein Families: Druggable Genome, P450
• Protein Pathways: Primary bile acid biosynthesis