FLASH (CASP8AP2) Rabbit Polyclonal Antibody

CAT#: TA351192

Rabbit Polyclonal Anti-CASP8AP2 Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Hela cells
  IHC: 25-100
  Positive control: Human brain
  Predicted cell location: Cytoplasm and Nucleus
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human CASP8AP2
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 223 kDa
• Gene Name: caspase 8 associated protein 2
• Database Link:
  NP_036247
  Entrez Gene 26885 MouseEntrez Gene 9994 Human
  UniProt ID Q9UKL3
• Background: This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
• Synonyms: CED-4; FLASH; RIP25

Reference Data

• Protein Families: Druggable Genome