IGF2R Rabbit Polyclonal Antibody

CAT#: TA351279

Rabbit Polyclonal Anti-IGF2R Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Jurkat cells
  IHC: 50-200
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human IGF2R
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 274 kDa
• Gene Name: insulin like growth factor 2 receptor
• Database Link:
  NP_000867
  Entrez Gene 16004 MouseEntrez Gene 3482 Human
  UniProt ID P11717
• Background: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
• Synonyms: CD222; CIMPR; M6P-R; MPR1; MPRI

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome