KDM5B Rabbit Polyclonal Antibody

CAT#: TA351325

Rabbit Polyclonal Anti-KDM5B Antibody

Product Images

Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Hela cells, MCF7 cells, Primary antibody: (KDM5B Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes

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  The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using (KDM5B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

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  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (KDM5B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1000-2000, WB: 200-1000, IHC: 50-200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human KDM5B
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 176 kDa
• Gene Name: lysine demethylase 5B
• Database Link:
  NP_006609
  Entrez Gene 10765 Human
  UniProt ID Q9UGL1
• Background: PLU-1 is a large (1,544 amino acid) nuclear protein that interacts with brain factor-1 (BF-1) and paired box 9 (PAX9), both of which are developmental transcription factors. PLU-1 belongs to the testis-cancer antigen group of proteins and is a member of the ARID family of DNA binding proteins. It is a multi-domain protein with strong transcriptional repression properties. PLU-1 shows restricted expression in adult tissues, with high expression in testis and transient expression in the pregnant mammary gland. Both the PLU-1 gene and the PLU-1 protein product are specifically upregulated in breast cancer. PLU-1 may be important in meiotic transcription because of its apparent association with chromatin.
• Synonyms: CT31; JARID1B; PLU-1; PLU1; PPP1R98; PUT1; RBBP2H1A

Reference Data

• Protein Families: Druggable Genome, Transcription Factors