Ryanodine Receptor (RYR1) Rabbit Polyclonal Antibody

CAT#: TA351617

Rabbit Polyclonal Anti-RYR1 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Mouse brain tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human RYR1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 565 kDa
• Gene Name: ryanodine receptor 1
• Database Link:
  NP_000531
  Entrez Gene 20190 MouseEntrez Gene 114207 RatEntrez Gene 6261 Human
  UniProt ID P21817
• Background: This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described.
• Synonyms: CCO; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Calcium signaling pathway, Long-term depression