BCR Mouse Monoclonal Antibody [Clone ID: 7C6]

CAT#: TA352923L

Mouse monoclonal Anti-BCRABL Clone 7c6

Specifications

Product Data

• Clone Name: 7C6
• Recommended Dilution: IF ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Bcr686 thyroglobulin conjugate
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 210
• Gene Name: BCR, RhoGEF and GTPase activating protein
• Database Link:
  NP_067585
  Entrez Gene 613 Human
  UniProt ID P11274
• Background: The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5' bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications.
• Synonyms: ALL; BCR1; CML; D22S11; D22S662; PHL

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chronic myeloid leukemia, Pathways in cancer