ASAP1 Mouse Monoclonal Antibody [Clone ID: 7B12]

CAT#: TA352983L

Mouse monoclonal Anti-ASAP1 Clone 7B12

Specifications

Product Data

• Clone Name: 7B12
• Recommended Dilution: ELISA ; IHC ; IP ; WB
• Reactivities: Human, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant Protein (fragment of human ASAP1 (corresponding nucleotides 977-1532 of KIAA1249) with N-terminal GST tag produced in E.coli strain BL-21)
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
• Database Link:
  NP_001234925
  Entrez Gene 314961 RatEntrez Gene 50807 Human
  UniProt ID Q9ULH1
• Background: ASAP1 possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. It may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. It potentially has involvement in tumour progression, having been shown to promote metastasis formation in vivo and stimulate tumor cell motility, invasiveness, and adhesiveness in vitro. ASAP1 represents a potential target for cancer therapy.
• Synonyms: AMAP1; CENTB4; DDEF1; PAG2; PAP; ZG14P
• Note: Other research areas applicable: Metastasis, cytoskeleton, vesicle trafficking.

Reference Data

• Protein Pathways: Endocytosis, Fc gamma R-mediated phagocytosis