CD22 Mouse Monoclonal Antibody [Clone ID: TPD44/D11]

CAT#: TA353034L

Mouse monoclonal Anti-SIGLEC2 Clone TPD44/D11

Specifications

Product Data

• Clone Name: TPD44/D11
• Recommended Dilution: FACS ; IHC
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: B cell lymphoma cells
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD22 molecule
• Database Link:
  NP_001172030
  Entrez Gene 933 Human
  UniProt ID P20273
• Background: SIGLEC-2 (CD22) is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC-2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC-2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC-2 is strongly expressed in hairy cell leukaemias.
• Synonyms: SIGLEC-2; SIGLEC2
• Note: Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: B cell receptor signaling pathway, Cell adhesion molecules (CAMs), Hematopoietic cell lineage