CLEC1B Mouse Monoclonal Antibody [Clone ID: AYP1]

CAT#: TA353099L

Mouse monoclonal Anti-CLEC2 Clone AYP1

Product Images

Western Blot analysis using anti-CLEC2 [AYP1]

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  Flow cytometric analysisi of CLEC-2 on platelets and leukocytes using anti-CLEC2 [AYP1].

Specifications

Product Data

• Clone Name: AYP1
• Applications: FC, WB
• Recommended Dilution: FACS ; IF ; IP ; Functional
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: A recombinant extracellular fragment of human CLEC-2 (aa 68-229), which is the extracellular domain of the protein
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 26 kDa
• Gene Name: C-type lectin domain family 1 member B
• Database Link:
  NP_001092901
  Entrez Gene 51266 Human
  UniProt ID Q9P126
• Background: Patients with rheumatoid arthritis, an inflammatory disease associated with increased microparticle production, have raised plasma levels of microparticles that expressed CLEC-2 but not GPVI. CLEC-2 can be used to monitor platelet-derived microparticles. The observation that microparticles derived from activated platelets retain CLEC-2 but lose GPVI highlights the potential use of measurement of surface expression of platelet receptors to screen for platelet activation in a wide variety of cardiovascular and inflammatory diseases.
• Synonyms: 1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721
• Note: AYP1 can block the interaction of human CLEC-2 with its endogenous ligand Podoplanin.

Reference Data

• Protein Families: Druggable Genome, Transmembrane