CD49b (ITGA2) Mouse Monoclonal Antibody [Clone ID: HAS-3]

CAT#: TA353244L

Mouse monoclonal Anti-Integrin a2 Clone HAS-3

Specifications

Product Data

• Clone Name: HAS-3
• Recommended Dilution: FACS ; IF ; IHC ; IP
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Whole human keratinocytes.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha 2
• Database Link:
  NP_002194
  Entrez Gene 3673 Human
  UniProt ID P17301
• Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin Ã?1 (CD29) to form the heterodimer integrin a2Ã?1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-3 co-precipitates integrin a2Ã?1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen.
• Synonyms: BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer