Integrin alpha 4 (ITGA4) Mouse Monoclonal Antibody [Clone ID: 7.2]

CAT#: TA353253L

Mouse monoclonal Anti-Integrin a4 Clone 7.2

Specifications

Product Data

• Clone Name: 7.2
• Recommended Dilution: FACS ; IHC ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human melanoma line DX3
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha 4
• Database Link:
  NP_000876
  Entrez Gene 3676 Human
  UniProt ID P13612
• Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 4 Combines with beta-1 integrin to form the Integrin alpha4/beta1 lymphocyte homing receptor: Very Late Antigen 4 (VLA-4). VLA-4 plays a major role in lymphocyte extravasation, via binding to VCAM on endothelial cells. VLA-4 also binds fibronectin and mediates homotypic and heterotypic cell-cell adhesion between lymphocytes.
• Synonyms: CD49D; IA4
• Note: Recommended for Histology on unfixed tissue culture cells.

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Regulation of actin cytoskeleton