Integrin alpha 6 (ITGA6) Mouse Monoclonal Antibody [Clone ID: MP4F10]

CAT#: TA353257L

Mouse monoclonal Anti-Integrin a6 Clone MP4F10

Specifications

Product Data

• Clone Name: MP4F10
• Recommended Dilution: FACS ; IHC ; IP
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: SW1222 human colorectal cell line.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha 6
• Database Link:
  NP_000201
  Entrez Gene 3655 Human
  UniProt ID P23229
• Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 6 is found on epithelial and endothelial basement membranes and colorectal carcinoma. Integrin alpha 6 associates with integrin beta 4 to form integrin a6b4, one of the most abundant keratinocyte integrins, and binds laminin. MP 4F10 may be used in clinical studies for tumour grading as it will stain both moderately and well-differentiated colorectal adenocarcinoma.
• Synonyms: CD49f; ITGA6B; VLA-6

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer