Claudin 7 (CLDN7) Rabbit Polyclonal Antibody

CAT#: TA354312

Rabbit anti Claudin 7 Polyclonal Antibody

Product Images

WB: The whole tissue lysates derived from mouse kidney were immunoblotted by Rabbit anti-Claudin 7 antibody at 1:500 (Lane 1). The immunoreactive band is blocked by preincubation of immunizing peptide (lane 2)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 0.5-2 µg/ml FC Not tested
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: peptide from C-terminus of human claudin 7 protein. This sequence is identical to human, rat, mouse and bovine.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 24 kDa
• Gene Name: claudin 7
• Database Link:
  NP_001171951
  Entrez Gene 53624 MouseEntrez Gene 65132 RatEntrez Gene 1366 Human
  UniProt ID O95471
• Background: The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four trans-membrane domains and two extracellular loops, make up tight junction strands. Claudin 7 (CLDN7) has two isoforms, a full-length form with 211 aa residues and a C-terminal truncated form with 158 aa residues. This protein is localized in the intercellular junctions of the epithelial cells of the proximal tubules of the nephrons in mammalian kidney. It is expressed in normal human and mouse epithelia.
• Synonyms: CEPTRL2; claudin-1; CLDN-7; CPETRL2; Hs.84359

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction