p21 (CDKN1A) Mouse Monoclonal Antibody [Clone ID: SPM306]
Other products for "CDKN1A"
Specifications
Product Data | |
Clone Name | SPM306 |
Applications | IHC |
Recommended Dilution | WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant human p57/Kip2 protein. |
Formulation | This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer. |
Purification | The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | ~21 kDa |
Gene Name | cyclin-dependent kinase inhibitor 1A |
Database Link | |
Background | p57/Kip 2 (or CDKN 1C) is a tight-binding strong inhibitor of several G1 cycline/Cdk complexes and a negative regulator of cell proliferation. The gene is a tumor suppressor which is located on chromosome 11p15.5. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome (BWS). Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin like growth factor II (IGF II) and H19, both of which seem to be implicated in adrenal neoplasms. |
Synonyms | CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Bladder cancer, Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Glioma, Melanoma, p53 signaling pathway, Pathways in cancer, Prostate cancer |
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