IL11 Rabbit Polyclonal Antibody

CAT#: TA355013

Rabbit Polyclonal Anti-IL-11 Antibody

USD 430.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1-2µg/mL. IHC: 10µg/ml.
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen IL-11 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-11. The immunogen is located within amino acids 40 - 90 of IL-11.
Formulation IL-11 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification IL-11 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 20 kDa; Observed: 19 kDa
Gene Name interleukin 11
Background Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).
Synonyms AGIF; IL-11; oprelvekin
Note IL-11 antibody can be used for the detection of IL-11 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry at 10 µg/ml.
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.