IL11 Rabbit Polyclonal Antibody

CAT#: TA355013

Rabbit Polyclonal Anti-IL-11 Antibody

Product Images

Western blot analysis of IL-11 in Hela Cell lysate with IL-11 antibody at 1ug/ml.

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  Immunofluorescence of IL-11 in HeLa cells with IL-11 antibody at 20ug/ml.

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  Immunocytochemistry of IL-11 in HeLa cells with IL-11 antibody at 10ug/ml.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1-2µg/mL. IHC: 10µg/ml.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-11 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-11. The immunogen is located within amino acids 40 - 90 of IL-11.
• Formulation: IL-11 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IL-11 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 20 kDa; Observed: 19 kDa
• Gene Name: interleukin 11
• Database Link:
  NP_000632
  Entrez Gene 3589 Human
  UniProt ID P20809
• Background: Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).
• Synonyms: AGIF; IL-11; oprelvekin
• Note: IL-11 antibody can be used for the detection of IL-11 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry at 10 µg/ml.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway