TRIM58 Rabbit Polyclonal Antibody

CAT#: TA355022

Rabbit Polyclonal Anti-TRIM58 Antibody

Product Images

Western blot analysis of TRIM58 in (A) human heart tissue and (B) mouse kidney lysate with TRIM58 antibody at 1ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1-2µg/mL.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRIM58 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TRIM58.
• Formulation: TRIM58 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TRIM58 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 53 kDa; Observed: 56 kDa
• Gene Name: tripartite motif containing 58
• Database Link:
  NP_056246
  Entrez Gene 216781 MouseEntrez Gene 303167 RatEntrez Gene 25893 Human
  UniProt ID Q8NG06
• Background: TRIM58 Antibody: TRIM58 is a member of the tripartite motif-containing family of proteins that frequently possess E3 ubiquitin ligase activities (1). TRIM58 is strongly expressed in erythroid lineage cells and is further upregulated during late erythroid maturation. Recent experiments suggest that TRIM58 facilitates erythroblast enucleation by ubiquitinating the intermediate chain of the microtubule motor dynein, thereby inducing proteolytic degradation (2).
• Synonyms: BIA2; DKFZp434C091
• Note: TRIM58 antibody can be used for Western blot at 1 - 2 µg/mL.

Reference Data

• Protein Families: Druggable Genome