ALK Mouse Monoclonal Antibody [Clone ID: 5A4]

CAT#: TA355215

ALK Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 5A4
• Applications: IHC
• Recommended Dilution: 1:200
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript (419-520αα)
• Specificity: Human ALK protein and C-terminal ALK fusion proteins containing the immunized target sequence.
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: anaplastic lymphoma receptor tyrosine kinase
• Database Link:
  Entrez Gene 238 Human
• Background: Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals and may be associated with cutaneous and extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23;q35). This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large cell lymphomas account for approximately 25% of all non-Hodgkin's lymphomas in children and young adults, of which one third carry the NPM-ALK gene translocation.
• Synonyms: CD246; NBLST3; TFG/ALK