bcl 6 (BCL6) Mouse Monoclonal Antibody [Clone ID: LN22]

CAT#: TA355224

Bcl-6 Oncoprotein Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: LN22
• Applications: IHC
• Recommended Dilution: 1:60
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein containing 1–350 amino acids of the N-terminus of the Bcl-6 human oncoprotein molecule
• Specificity: Human Bcl-6 oncoprotein
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: B-cell CLL/lymphoma 6
• Database Link:
  Entrez Gene 604 Human
• Background: Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of 95 kD and shares homology with other transcription factors. Bcl-6 protein is mainly expressed in normal germinal center B cells and related lymphomas. It has been shown that the Bcl-6 proto-oncogene is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have also been detected in 33-45% of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the Bcl-6 gene product to be detectable in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
• Synonyms: BCL-5; BCL-6; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51