Alpha Dystroglycan (DAG1) Mouse Monoclonal Antibody [Clone ID: 43DAG1/8D5]

CAT#: TA355226

Beta-Dystroglycan Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 43DAG1/8D5
• Applications: IHC
• Recommended Dilution: 1:50-1:200
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Synthetic peptide containing 15 of the last 16 amino acids at the extreme C-terminus of the human beta-dystroglycan sequence (PKNMTPYRSPPPYVP-PCOOH)
• Specificity: Human beta-dystroglycan (43 kD). Also crossreacts strongly with beta-dystroglycan in sections of mouse, rat, rabbit, dog and chicken, hamster and toad muscle. Other animal species not tested.
• Formulation: Lyophilized tissue culture supernatant containing sodium azide as a preservative.
• Reconstitution Method: The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: dystroglycan 1
• Database Link:
  Entrez Gene 1605 Human
• Background: Dystrophin associated glycoproteins (DAGs) are involved in the attachment of dystrophin to muscle membranes. The biological significance of this dystrophin/glycoprotein complex is not fully understood, but it appears to form an essential linkage between actin on the inside of the muscle fiber and muscle laminin in the basal lamina which surrounds the fiber. Beta-dystroglycan spans the sarcolemma and it has been suggested that it is the member of the complex which binds directly to dystrophin.
• Synonyms: 156DAG; A3a; AGRNR; alpha-dystroglycan; beta-dystroglycan; DAG