Her2 (ERBB2) Mouse Monoclonal Antibody [Clone ID: CB11]
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Specifications
Product Data | |
Clone Name | CB11 |
Applications | IHC |
Recommended Dilution | 1:40 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Synthetic peptide corresponding to a site on the internal domain of the human c-erbB-2 oncoprotein |
Specificity | Human c-erbB-2 oncoprotein (internal domain). Specific binding has been demonstrated by immunoprecipitation with c-erbB-2 oncoprotein SKBR3 cells |
Formulation | Liquid tissue culture supernatant containing sodium azide as a preservative |
Conjugation | Unconjugated |
Storage | Store at 2-8°C |
Stability | 12 months |
Gene Name | erb-b2 receptor tyrosine kinase 2 |
Database Link | |
Background | The c-erbB-2 oncoprotein is closely related in structure to the epidermal growth factor receptor and is a member of a large family of cell surface growth factor receptors. c-erbB-2 oncoprotein is reported to be detectable in a proportion of breast and other adenocarcinomas as well as transitional cell carcinomas. c-erbB-2 oncoprotein is present in a wide variety of cell types in a range of normal human fetal and adult tissues, including breast, stomach and ovary. CB11 detects the internal domain of the c-erbB-2 oncoprotein. CBE-356 detects the external domain of the c-erbB-2 oncoprotein. |
Synonyms | C-erbB-2; CD340; erbB-2; HER-2; HER-2/neu; HER2; herstatin; NEU; NGL; p185erbB2; TKR1 |
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