Mesothelin (MSLN) Mouse Monoclonal Antibody [Clone ID: 5B2]

CAT#: TA355314

Mesothelin Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 5B2
• Applications: IHC
• Recommended Dilution: 1:40
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant prokaryotic fusion protein corresponding to approximately 100 amino acids which are present in the membrane-bound form of the mesothelin molecule.
• Specificity: Human mesothelin
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: mesothelin
• Database Link:
  Entrez Gene 10232 Human
• Background: Mesothelin is a glycosyl-phosphatidylinositol-linked (GPI) glycoprotein of 40kD present on the surface of mesothelial cells, mesotheliomas, epithelial ovarian cancers and some squamous cell carcinomas. It is synthesized as a 69 kD precursor which is enzymatically processed into an N-terminal secreted form of 30 kD and the GPI-linked membrane-bound form of 40 kD. The secreted form is identical to the megakaryocyte potentiating factor, but it is the GPI-linked membrane-bound form which has generated interest. Mesothelin is abundantly expressed in the kidney and in occasional epithelial cells of the trachea, tonsil and fallopian tube. The function of mesothelin is unclear but it may have a role in cellular adhesion. Mesothelin is reported to be abundant in the normal mesothelial cells from which malignant mesotheliomas and ovarian cystadenocarcinomas are derived.
• Synonyms: CAK1; mesothelin; MPF; SMR