MITF Mouse Monoclonal Antibody [Clone ID: 34CA5]

CAT#: TA355315

Microphthalmia Transcription Factor (MITF) Mouse Monoclonal Antibody

Specifications

Product Data

• Clone Name: 34CA5
• Applications: IHC
• Recommended Dilution: 1:10 - 1:20
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to 111 amino acids of the N-terminal region of the MITF-M molecule
• Specificity: Human microphthalmia transcription factor, MITF-M isoform
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: melanogenesis associated transcription factor
• Database Link:
  Entrez Gene 4286 Human
• Background: Microphthalmia transcription factor (MITF) gene product, a nuclear transcription factor of the basic-helix-loop-helix type, is thought to play a role in the regulation of genes encoding the enzymes necessary for melanogenesis. These include tyrosinase, TRP-1 and TRP-2. MITF is critical for the embryonic development and postnatal viability of melanocytes. The melanocyte-specific isoform of microphthalmia transcription factor MITF-M, is reported to be expressed in normal and malignant melanocytes. The other isoforms, MITF-A, MITF-C and MITF-H, differ structurally at the N-terminus from MITF-M.
• Synonyms: bHLHe32; MI; WS2A