NOTCH4 Rabbit Polyclonal Antibody

CAT#: TA355566

NOTCH4 Antibody - middle region

Product Images

Host: Rabbit Target Name: NOTCH4 Sample Tissue: Human Lung Tumor Antibody Dilution: 1.0ug/ml

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  Immunohistochemistry with Human Breast tissue at an antibody concentration of 5.0ug/ml using anti-NOTCH4 antibody (TA355566)

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NOTCH4
• Specificity: Expected reactivity: Cow, Guinea Pig, Horse, Human, Pig, Rat
  Homology: Cow: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Pig: 100%; Rat: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 61kDa
• Gene Name: notch 4
• Database Link:
  Entrez Gene 4855 Human
  UniProt ID Q99466-2
• Background: NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. NOTCH4 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH4 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. NOTCH4 gene may be associated with susceptibility to schizophrenia in a small portion of cases.
• Synonyms: FLJ16302; hNotch4; INT3; MGC74442; NOTCH3