SAFB Rabbit Polyclonal Antibody

CAT#: TA355977

SAFB Antibody - N-terminal region

Product Images

Host: Rabbit Target Name: SAFB Sample Tissue: Human THP-1 Whole Cell lysates Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SAFB
• Specificity: Expected reactivity: Human
  Homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rat: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 93 kDa
• Gene Name: scaffold attachment factor B
• Database Link:
  NP_002958.2
  Entrez Gene 6294 Human
  UniProt ID Q15424-2
• Background: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements(S/MAR DNA). This protein is thought to be involved in attachingthe base of chromatin loops to the nuclear matrix but there isconflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factorsare a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serveas a molecular base to assemble a 'transcriptosome complex' in thevicinity of actively transcribed genes. It is involved in theregulation of heat shock protein 27 transcription, can act as anestrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcriptvariants encoding different isoforms have been found for this gene.
• Synonyms: DKFZp779C1727; HAP; HET; SAB-B1; SAF-B; SAFB1