Dkk4 Rabbit Polyclonal Antibody

CAT#: TA356188

Dkk4 Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: Dkk4 Antibody Dilution: 1.0ug/ml Sample Type: Mouse Pancreas

Specifications

Product Data

• Applications: WB
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
  Homology: Dog: 93%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 100%; Rabbit: 79%; Rat: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 24kDa
• Gene Name: dickkopf WNT signaling pathway inhibitor 4
• Database Link:
  NP_663567
  Entrez Gene 234130 Mouse
  UniProt ID Q8VEJ3
• Background: Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
• Synonyms: Dickkopf-4; DKK-4; hDkk-4; MGC129562; MGC129563