Tapasin (TAPBP) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | IHC, WB |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human TAPBP |
Specificity | Expected reactivity: Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep Homology: Dog: 93%; Horse: 93%; Human: 100%; Mouse: 79%; Pig: 93%; Rabbit: 93%; Rat: 86%; Sheep: 79% |
Formulation | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Predicted Protein Size | 30kDa |
Gene Name | TAP binding protein (tapasin) |
Database Link | |
Background | TAPBP is a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. |
Synonyms | NGS17; TAPA; TPN; TPSN |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Antigen processing and presentation |
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