TGF beta 2 (TGFB2) Rabbit Polyclonal Antibody

CAT#: TA356540

TGFB2 Antibody - middle region

Product Images

WB Suggested Anti-TGFB2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: NCI-H226 cell lysateThere is BioGPS gene expression data showing that TGFB2 is expressed in NCIH226

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  Host: Rabbit Target Name: TGFB2 Sample Tissue: Mouse Small Intestine Antibody Dilution: 1ug/ml

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  Host: Mouse Target Name: TGFB2 Sample Tissue: Mouse Small Intestine Antibody Dilution: 1ug/ml

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  Host: Rabbit Target: TGFB2 Positive control (+): THP-1 (N30) Negative control (-): U937 (N31) Antibody concentration: 3ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TGFB2
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Zebrafish
  Homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 46kDa
• Gene Name: transforming growth factor beta 2
• Database Link:
  NP_003229
  Entrez Gene 21808 MouseEntrez Gene 7042 Human
  UniProt ID P61812
• Background: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Synonyms: Cetermin; G-TSF; MGC116892; Polyergin; TGF-beta-2; TGF-beta2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway