ATRX Rabbit Polyclonal Antibody

CAT#: TA356679

ATRX Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: ATRX Sample Type: Jurkat Whole Cell lysates Antibody Dilution: 1.0ug/mlATRX is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX
• Specificity: Expected reactivity: Dog, Human, Pig, Rabbit
  Homology: Dog: 88%; Human: 100%; Pig: 93%; Rabbit: 75%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 148kDa
• Gene Name: ATRX, chromatin remodeler
• Database Link:
  Entrez Gene 546 Human
  UniProt ID P46100-6
• Background: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Synonyms: ATR2; MGC2094; MRXHF1; RAD54; RAD54L; SFM1; SHS; XH2; XNP; ZNF-HX