CTPS2 Rabbit Polyclonal Antibody

CAT#: TA358180

CTPS2 Antibody - N-terminal region

Product Images

WB Suggested Anti-CTPS2 Antibody Titration: 1.0 ug/ml Positive Control: Hela Whole CellCTPS2 is supported by BioGPS gene expression data to be expressed in HeLa

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  Sample Type: Human Hep-2 cells Primary Antibody Dilution: 1:500 Secondary Antibody: Goat anti-rabbit-Alexa Fluor 568 Secondary Antibody Dilution: 1:400 Color/Signal Descriptions: Red: CTPS2 Blue: DAPI Gene Name: CTPS2 Submitted by: S. John Calise, Edward Chan Lab, University of Florida

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
  Homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 64kDa
• Gene Name: CTP synthase 2
• Database Link:
  NP_787055
  Entrez Gene 56474 Human
  UniProt ID Q9NRF8
• Background: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
• Synonyms: DKFZp686C17207; FLJ43358; MGC32997

Reference Data

• Protein Pathways: Metabolic pathways, Pyrimidine metabolism