HCAR2 Rabbit Polyclonal Antibody

CAT#: TA358555

HCAR2 Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: HCAR2 Sample Tissue: Human Stomach Tumor Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Guinea Pig, Human, Mouse, Rabbit, Rat
  Homology: Cow: 91%; Guinea Pig: 92%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 42kDa
• Gene Name: hydroxycarboxylic acid receptor 2
• Database Link:
  NP_808219
  Entrez Gene 338442 Human
  UniProt ID Q8TDS4
• Background: HCAR2 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
• Synonyms: GPR109A; HCA2; HM74a; HM74b; NIACR1; Puma-g; PUMAG

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane