WISP2 Rabbit Polyclonal Antibody

CAT#: TA358642

WISP2 Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: WISP2 Antibody Dilution: 1.0ug/ml Sample Type: Human Placenta

• 

  HeLaWISP2 is supported by BioGPS gene expression data to be expressed in HeLa

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Dog, Horse, Human, Pig, Rat
  Homology: Dog: 79%; Horse: 79%; Human: 100%; Pig: 79%; Rat: 79%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 24kDa
• Gene Name: WNT1 inducible signaling pathway protein 2
• Database Link:
  NP_003872
  Entrez Gene 8839 Human
  UniProt ID O76076
• Background: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
• Synonyms: CCN5; CT58; CTGF-L; CTGFL; OTTHUMP00000063227; WISP-2

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein