UGT1A4 Rabbit Polyclonal Antibody

CAT#: TA359749

UGT1A4 Antibody - N-terminal region

Product Images

Host: Rabbit Target Name: UGT1A4 Sample Tissue: Human Liver Tumor lysates Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UGT1A4
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 58 kDa
• Gene Name: UDP glucuronosyltransferase family 1 member A4
• Database Link:
  NP_009051.1
  Entrez Gene 54657 Human
  UniProt ID P22310
• Background: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
• Synonyms: GNT1; HUG-BR2; UDP-glucuronosyltransferase; UDPGT; UGT-1D; UGT1; UGT1*4; UGT1-04; UGT1.4; UGT1D