KCNQ2 Rabbit Polyclonal Antibody

CAT#: TA360139

KCNQ2 Antibody - middle region

Product Images

WB Suggested Anti-KCNQ2 antibody Titration: 1 ug/mL Sample Type: Human 293T Whole Cell

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human KCNQ2
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 95 kDa
• Gene Name: potassium voltage-gated channel subfamily Q member 2
• Database Link:
  Entrez Gene 3785 Human
  UniProt ID O43526
• Background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
• Synonyms: BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KV7.2; KVEBN1