DIO2 Rabbit Polyclonal Antibody

CAT#: TA360550

DIO2 Antibody - middle region

Product Images

Host: Rabbit Target Name: DIO2 Sample Tissue: ACHN Whole Cell lysates Antibody Dilution: 1ug/ml

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  Host: Rat Target Name: DIO2 Sample Tissue: Rat Skeletal Muscle Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DIO2
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 30 kDa
• Gene Name: deiodinase, iodothyronine, type II
• Database Link:
  NP_000784.2
  Entrez Gene 1734 Human
  UniProt ID Q92813
• Background: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Synonyms: 5DII; D2; DIOII; ITDI2; SelY; TXDI2