VDAC1 Rabbit Polyclonal Antibody

CAT#: TA365439

VDAC1 rabbit polyclonal antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane 1-3: Jurkat cell 293T cell Mouse kidney tissue lysates Primary antibody: TA365439 (VDAC1 Antibody) at dilution 1/1150 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 30 seconds

• 

  Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA365439 (VDAC1 Antibody) at dilution 1/150 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA365439 (VDAC1 Antibody) at dilution 1/150, treated with fusion protein. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA365439 (VDAC1 Antibody) at dilution 1/150 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA365439 (VDAC1 Antibody) at dilution 1/150, treated with fusion protein. (Original magnification: ×200)

Show all 5 images

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Jurkat cell, 293T cell, Mouse kidney tissue lysates
  IHC: 150-300
  Positive control: Human prostate cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human VDAC1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Predicted Protein Size: 31 kDa
• Database Link:
  UniProt ID P21796
• Background: Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria. In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics. Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c. In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3.