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CLACP (COL25A1) Rabbit Polyclonal Antibody
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Other products for "COL25A1"
Specifications
| Product Data | |
| Applications | IHC |
| Recommended Dilution | IHC: 20-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivities | Human, Mouse |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human COL25A1 |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C. |
| Stability | 1 year |
| Gene Name | collagen type XXV alpha 1 |
| Database Link | |
| Background | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | AMY; CLAC; CLAC-P; CLACP; OTTHUMP00000196081; OTTHUMP00000196082 |
| Reference Data | |
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