ISY1 Rabbit Polyclonal Antibody

CAT#: TA377591

ISY1 Rabbit polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB,1:500 - 1:2000
• Reactivities: Human, Mouse
• Modifications: Unmodified
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human ISY1 (NP_001186398.1).
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 32kDa/35kDa/37kDa
• Gene Name: ISY1 splicing factor homolog
• Database Link:
  Entrez Gene 57461 Human
  UniProt ID Q9ULR0
• Background: Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity. Required during the transition of embryonic stem cells (ESCs from the naive to primed state (By similarity. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity. Involved in pre-mRNA splicing as component of the spliceosome.