Aryl hydrocarbon Receptor (AHR) Rabbit Monoclonal Antibody [Clone ID: R07-1H9]

CAT#: TA383686

Aryl Hydrocarbon Receptor Rabbit monoclonal Antibody

Product Images

Western blot detection of Aryl hydrocarbon Receptor in Hela cell lysates using Aryl hydrocarbon Receptor Rabbit mAb(1:1000 diluted).Predicted band size:96kDa.Observed band size:100kDa.

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  Immunocytochemistry of Aryl hydrocarbon Receptor(green) in Hela cells using Aryl hydrocarbon Receptor Rabbit mAb at dilution 1/50, and DAPI(blue)

Specifications

Product Data

• Clone Name: R07-1H9
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Aryl hydrocarbon Receptor
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 96 kDa; Observed MW: 100 kDa
• Gene Name: aryl hydrocarbon receptor
• Database Link:
  Entrez Gene 196 Human
  UniProt ID P35869
• Background: Swiss-Prot Acc.P35869.Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
• Synonyms: AH-receptor; bHLHe76