SERCA2 (ATP2A2) Rabbit Monoclonal Antibody [Clone ID: R09-1G2]

CAT#: TA383783

SERCA2 ATPase Rabbit monoclonal Antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

Product Images

Other products for "ATP2A2"

Specifications

Product Data
Clone Name R09-1G2
Applications IF, IHC, WB
Recommended Dilution WB: 1/2000-1/10000
IHC: 1/20
ICC/IF: 1/50-1/100
Reactivities Human, Rat
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic peptide of human SERCA2 ATPase
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Stability 1 year
Predicted Protein Size Calculated MW: 115 kDa; Observed MW: 115 kDa
Gene Name ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Background Swiss-Prot Acc.P16615.This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation .
Synonyms ATP2B; DAR; DD; DKFZp686P0211; FLJ20293; FLJ38063; MGC45367; SERCA2
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.