CMKLR1 Rabbit Polyclonal Antibody

CAT#: TA384017

CMKLR1 Rabbit polyclonal Antibody

Product Images

Western Blot analysis of various cells using ChemR23 Polyclonal Antibody diluted at 1：1000

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  Western Blot analysis of COLO205 cells using ChemR23 Polyclonal Antibody diluted at 1：1000

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  Western blot analysis of 293T lysis using ChemR23 antibody. Antibody was diluted at 1:1

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  Western blot analysis of 293T lysis using ChemR23 antibody. Antibody was diluted at 1:1000

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  Western blot analysis of lysates from HeLa and HUVEC cells, using CMKLR1 Antibody. The lane on the right is blocked with the synthesized peptide.

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Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: WB: 1/500-1/2000
  IHC: 1/100-1/300
  IF: 1/200-1/1000
  ELISA: 1/20000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized peptide derived from human CMKLR1. AA range:221-270
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Observed MW (kDa):42
• Database Link:
  UniProt ID Q99788
• Background: Swiss-Prot Acc.Q99788.Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).