PERK (EIF2AK3) Rabbit Monoclonal Antibody [Clone ID: R09-1F9]
Other products for "EIF2AK3"
Specifications
Product Data | |
Clone Name | R09-1F9 |
Applications | WB |
Recommended Dilution | WB: 1/1000 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | Recombinant protein of human PERK |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Stability | 1 year |
Predicted Protein Size | Calculated MW: 125 kDa; Observed MW: 140 kDa |
Gene Name | eukaryotic translation initiation factor 2 alpha kinase 3 |
Database Link | |
Background | Swiss-Prot Acc.Q9NZJ5.Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. |
Synonyms | DKFZp781H1925; HRI; HsPEK; PEK; PERK; WRS |
Reference Data |
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