KCNQ2 Rabbit Polyclonal Antibody

CAT#: TA384588

Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Rabbit polyclonal Antibody

Product Images

Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Kv7.3/KCNQ3 (Phospho-Thr246) Antibody

• 

  Immunohistochemistry analysis of paraffin-embedded human brain, using Kv7.3/KCNQ3 (Phospho-Thr246) Antibody. The picture on the right is blocked with the phospho peptide.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 1/100-1/300
  ELISA: 1/20000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240 (Phosphorylated)
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Gene Name: potassium voltage-gated channel subfamily Q member 2
• Database Link:
  Entrez Gene 3785 Human
  UniProt ID O43526
• Background: Swiss-Prot Acc.O43526/O43525/P56696/Q9NR82.The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
• Synonyms: BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KV7.2; KVEBN1