LYN Mouse Monoclonal Antibody [Clone ID: 1C8-H3-G6]

CAT#: TA384684

Lyn (1C8) Mouse monoclonal Antibody

Product Images

Western blot detection of Lyn in Ramos,Raji,K562 and Hela cell lysates using Lyn mouse mAb(dilution 1:1000).Predicted band size:56/53kDa.Observed band size:56/53kDa.

Specifications

Product Data

• Clone Name: 1C8-H3-G6
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant human Lyn protein fragments expressed in E.coli.
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 56/53kDa
• Gene Name: LYN proto-oncogene, Src family tyrosine kinase
• Database Link:
  Entrez Gene 4067 Human
  UniProt ID P07948
• Background: Swiss-Prot Acc.P07948.Down regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.
• Synonyms: FLJ26625; JTK8