Myelin Basic Protein (MBP) Rabbit Monoclonal Antibody [Clone ID: R08-9K4]
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Specifications
Product Data | |
Clone Name | R08-9K4 |
Applications | WB |
Recommended Dilution | WB: 1/1000 |
Reactivities | Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human Myelin Basic Protein |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Stability | 1 year |
Predicted Protein Size | Calculated MW: 33 kDa; Observed MW: 18 kDa |
Gene Name | myelin basic protein |
Database Link | |
Background | Swiss-Prot Acc.P02686.The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
Synonyms | Golli-mbp; MGC99675; OTTHUMP00000174383 |
Reference Data |
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