hnRNP G (RBMX) Rabbit Monoclonal Antibody [Clone ID: R03-1C9]

CAT#: TA385146

hnRNP G Rabbit monoclonal Antibody

Product Images

Western blot detection of hnRNP G in K562,Hela cell lysates using hnRNP G Rabbit mAb(1:1000 diluted).Predicted band size:42kDa.Observed band size:42kDa.

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  Immunohistochemistry of hnRNP G in paraffin-embedded Human lung cancer tissue using hnRNP G Rabbit mAb at dilution 1/20

Specifications

Product Data

• Clone Name: R03-1C9
• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/20-1/100
  ICC/IF: 1/20-1/50
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human hnRNP G
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 42 kDa; Observed MW: 42 kDa
• Gene Name: RNA binding motif protein, X-linked
• Database Link:
  Entrez Gene 27316 Human
  UniProt ID P38159
• Background: Swiss-Prot Acc.P38159.RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
• Synonyms: hnRNP-G; HNRPG; RBMXP1; RBMXRT; RNMX