CD40L (CD40LG) Human Monoclonal Antibody [Clone ID: hu5c8 (Ruplizumab)]

CAT#: TA385961

Recombinant Anti-CD40L (Clone hu5c8 (Ruplizumab))

Product Images

Western Blot using anti-OX40L antibody Ab00447 Rat spleen (lane 1), rat muscle (lane 2), rat bladder (lane 3), human breast tumour (lane 4) and human thyroid tumour (lane 5) samples were resolved on a 10% SDS PAGE gel and blots probed with TA385961 at 1 µg/ml before being detected by a secondary antibody. The expected band size (29 kDa) is seen in the human-derived samples, as well as bands corresponding to dimers and other multimers.

Specifications

Product Data

• Clone Name: hu5c8 (Ruplizumab)
• Applications: FC, WB
• Reactivities: Human
• Modifications: NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
• Host: Human
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Human CD40L
• Specificity: The antibody binds to CD40L with an IC50 of 0.845 ug/ml.
  
  The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531 ± 155 hours.
• Formulation: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
• Stability: 3 years from dispatch.
• Gene Name: CD40 ligand
• Database Link:
  Entrez Gene 959 Human
  UniProt ID P29965
• Synonyms: CD40-L; CD40L; CD154; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP