CD28 Mouse Monoclonal Antibody [Clone ID: 1C6]

CAT#: TA385977

Recombinant Anti-CD28 (Clone 1C6)


USD 523.00

2 Weeks*

Size
    • 200 ug

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Specifications

Product Data
Clone Name 1C6
Applications Bl, ELISA, FC
Reactivities Dog
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Canine CD28.
Specificity

The antibody binds specifically to canine CD28, a self self surface receptor expressed by thymocytes and a subset of natural killer cells. CD28 acts as a receptor for CD80 and CD86, providing a costimulatory signal for the activation of T-cells and the production of interleukins, such as IL-6. The 1C6 monoclonal antibody has antagonistic activity, blocking mixed lymphocyte reactions and cytotoxic T lymphocyte mediated killing. The use of the monoclonal antibody 1C6 for the neutralisation of CD26 signal following T-cell receptor activation is of clinical importance for transplantation therapy, as it has been shown to prevent graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT).
Formulation PBS with 0.02% Proclin 300.
Concentration lot specific
Conjugation Unconjugated
Storage Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Stability 3 years from dispatch.
Synonyms MGC138290; Tp44
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.