Integrin alpha 4 (ITGA4) Rabbit Monoclonal Antibody [Clone ID: Natalizumab]

CAT#: TA386071

Recombinant Anti-Integrin alpha 4 (Clone Natalizumab)

Product Images

Flow-cytometry using the anti-Integrin alpha 4 research biosimilar antibody Natalizumab (Ab00716) Human lymphocytes were stained with an isotype control (Ab00102-23.0, panel A) or the rabbit-chimeric version of Natalizumab (TA386071, panel B) at a concentration of 1 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a AF488 conjugated donkey anti-rabbit antibody (ab150073) and cells analysed on a FACSCanto flow-cytometer.

Specifications

Product Data

• Clone Name: Natalizumab
• Applications: FC
• Reactivities: Human
• Modifications: NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
• Host: Rabbit
• Isotype: IgG, kappa
• Clonality: Monoclonal
• Immunogen: The RAMOS cell line, a non-EBV releasing cell line, injected into mice.
• Specificity: This antibody binds to the alpha 4 binds subunit of α4β1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin
  
  This antibody binds to human integrin alpha 4 and has been used to treat Multiple Sclerosis and Crohn's Disease.
• Formulation: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
• Stability: 3 years from dispatch.
• Gene Name: integrin subunit alpha 4
• Database Link:
  Entrez Gene 3676 Human
  UniProt ID P13612
• Synonyms: CD49D; IA4; MGC90518; VLA-4