MHC I Rabbit Monoclonal Antibody [Clone ID: R1-9.6]

CAT#: TA386134

Recombinant Anti-MHC I (Clone R1-9.6)


USD 523.00

2 Weeks*

Size
    • 200 ug

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Specifications

Product Data
Clone Name R1-9.6
Applications IF, IP, R
Reactivities Mouse
Modifications This chimeric rabbit antibody was made using the variable domain sequences of the original format, for improved compatibility with existing reagents, assays and techniques.
Host Rabbit
Isotype IgG, kappa
Clonality Monoclonal
Immunogen This antibody was raised by immunising Lewis 1F rats with mouse CH-1 lymphoma cells. Spleen cells from immunised rats were fused with X-63Ag8-653 myeloma cells to generate hybridomas.
Specificity This antibody is specific for murine MHC class I, and binds to polymorphic H-2 determinants expressed on most haplotypes. This antibody is, therefore, able to bind all H-2 class I molecules, independent of the allele. This antibody recognises a determinant distinct from those detected by most common mouse monoclonal anti-H-2 antibodies.

This antibody binds murine H-2 MHC class I molecules, and has been used in both structural and biochemical studies. This antibody has been used in immunoprecipitation analysis (Robinson, 1987), and in immunofluorescence assays for MHC-I surface expression (Karacsonyi et al, 2004) and MHC-I endocytosis (Knorr et al, 2009).This antibody has also been employed to induce clustering of cell surface MHC-I in co-patching assays (Knorr et al, 2009). Cellular radioimmune assays have been used to confirm the binding of this antibody to spleen cells, and assess its strain specificity (Koch et al, 1983).
Formulation PBS with 0.02% Proclin 300.
Concentration lot specific
Conjugation Unconjugated
Storage Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Stability 3 years from dispatch.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.